My favorite way to compile Mutt is:

   sudo port install mutt-devel +smtp +ssl +imap +sasl +headercache

This allows me to check GMAIL IMAP, and send using Gmail's SMTP server.

Lifehacker has an article on setting up mutt and gmail

OMG PONIES: Solarized Themes for Mutt

Querying OS X's Address Book for matching email addresses: Hooking OS X's address book to Mutt

Opening URLs is easy with OS X's built in "Open URL" service. Especially when you give it a keyboard shortcut!

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